The CDC Guidelines Recommend Informing ALL Sexually Active Adults and Adolescents and ALL Injection Drug Users About PrEP.1

The CDC guidelines state to use the following criteria to identify if adults and adolescents weighting at least 35 kg are candidates for PrEP.

Please note: People who request PrEP should be offered it, even when no risk behaviors are identified. Studies have shown that people may not disclose certain behaviors to their health care provider even though they are at risk. Those criteria include people who are confirmed to be HIV-negative* and:


Are sexually active (anal or vaginal sex in the past 6 months) AND have any of the following:

  • Sexual partner(s) living with HIV (especially if their viral load is detectable or unknown)
  • Bacterial STI in the past 6 months
  • History of inconsistent or no condom use with sexual partner(s)

Are people who inject drugs and:

  • Have an injection partner who is living with HIV


  • Share injection equipment


  • are assessed to have sexual risk of HIV acquisition

* It is vital that people who may benefit from PrEP (PWBP) have a documented negative HIV test (ideally with a laboratory-based combination HIV antigen/antibody test) result within 1 week before receiving their initial PrEP dose and must not have any signs or symptoms of acute HIV infection.2 PWBP must also meet clinical eligibility based on the product they choose with their prescriber, which may require additional testing.

PrEP services in your area

As new PrEP products are approved by FDA, please be aware there may be a delay in resources and guideline updates


  1. Centers for Disease Control and Prevention (CDC). Pre-exposure prophylaxis (PrEP). Updated June 11, 2021. Accessed October 26, 2021.
  2. Department of Health and Human Services. Symptoms of HIV. Updated July 1, 2020. Accessed October 13, 2021.

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