What Is PrEP?

PrEP is the use of antiretroviral medications before potential HIV exposure to prevent HIV acquisition. Because PrEP uses antiretroviral medications, confirming HIV negative status immediately prior to initiation is critical.1


PrEP has received a grade A recommendation from the US Preventive Services Task Force (USPSTF) meaning that there is high certainty that the net benefit of this service is substantial. More details are available in the USPSTF full recommendation.2

Information about the full USPSTF recommendation

Who Can Prescribe PrEP?

Any licensed prescriber can prescribe PrEP, regardless of subspecialization. Primary care providers may be uniquely positioned to inform sexually active adolescents and adults about PrEP and identify those who might benefit from PrEP.1


As new PrEP products are approved by FDA, please be aware there may be a delay in resources and guideline updates


  1. Centers for Disease Control and Prevention (CDC). Pre-exposure prophylaxis (PrEP). Updated June 11, 2021. Accessed October 13, 2021. https://www.cdc.gov/hiv/clinicians/prevention/
  2. U.S. Preventive Services Task Force (USPSTF). Prevention of human immunodeficiency virus (HIV) infection: preexposure prophylaxis. Published June 11, 2019. Accessed October 13, 2021. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis

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This web portal is intended as an educational resource for healthcare providers practicing in the United States. It may include information about products or uses that have not been approved by the US Food and Drug Administration.

If you are not a healthcare provider, please discuss any questions you have regarding your health or medicines with your doctor, pharmacist, or nurse.